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School of Pharmacy

Tianjin University




		姜申德 教授

Prof. Shende Jiang Department of Medicinal Chemistry School of Pharmaceutical Science and Technology Tianjin University Tianjin 300072 P. R. China



1979.9 - 1983.7   山东聊城师范学院化学系理学学士
1983.9 - 1986.7   山东医科大学药学系理学硕士。
1986.9 - 1988.9   山东师范大学化学系助教
1988.10 - 1991.10  英国诺丁汉大学继续教育学系和化学系莱弗休姆基金学者
1991.11 - 1992.9   英国诺丁汉理工学院化学系访问学者
1992.10 - 1996.4   英国提塞德大学化学系哲学博士
1996.5 - 2002.9   英国桑德兰大学药学系博士后
2002.10 - 2003.4   英国赫瑞-瓦特大学化学系博士后
2003.5 - 2004.5   英国纽卡斯尔大学化学系博士后
2004.6 至今   天津大学药物科学与技术学院教授



1986年到1988年在山东师范大学化学系工作期间主持研制的安索杀菌剂(菌毒清)在1995年和1996年分别获得山东科 技进步二等奖和国家科技进步三等奖,该产品在国内有多家工厂生产,是广泛应用的杀菌消毒剂。1988年到2004年在英 国学习和工作期间从事过中日比较成人教育,包括从中国的洋务运动和日本明治维新到二战时期的社会发展历史,后来转回从事有机合成方法研究,利用铑类卡宾化合物产生叶立德进行б迁移重排反应不对称合成含氧杂环类结构化合物, 以单糖为手性原料进行有关立体选择合成方法方面的研究及天然产物的合成研究,其中包括莽草酸及其含氟衍生物的化学合成,和企业合作从事原料药的工艺开发研究, 从事过氟标记化学在正电子发射断层显像(Positron Emission Tomography, 简称PET)药物合成中的应用,特别是新型的碘鎓盐化学用于氟-18的芳香环亲核标记临床诊断帕金森氏症和老年痴呆症方面的放射性药物的研究。 2004年回到天津大学从事教学和科研工作,讲授本科生药物化学专业课,科研方面主要工作包括正电子发射断层显像放射性药物的研究,原料药及中间体的新工艺开发研究,同药物和化工企业合作比较多。



Shende Jiang was born (1963) and raised in the rural area of Shandong peninsula (P. R. China). He studied chemistry (B.Sc. in 1983) at Liaocheng Normal College (formerly Shandong Normal College Liaocheng Branch and now Liaocheng University) and medicinal chemistry (M.Sc. in 1986) under the supervision of Prof. Huicai Wang at Shandong Medical University (now part of Shandong University). From 1986 to 1988 he was a lecturer of organic chemistry in the chemistry department of Shandong Normal University, where he worked with the late Prof. Mingli Shi on the synthesis and development of amphoteric surfactants and other fine organic intermediates for the chemical and pharmaceutical industry. During that two years they had developed the best selling antibacterial agent Ansuojunkang (Junduqing) that has been massively manufactured in China since 1990 by a number of companies with production of more than 7000 tons each year.

He went to the UK in late 1988 with a scholarship from the Leverhulme Trust (1988-1991) at the University of Nottingham where he initially stayed in the department of adult education with Prof. Teddy Thomas and the late Prof. Michael D. Stephens studying comparative adult education on China and Japan, and later moved to Prof. J. Stephen Clark's group in the department of chemistry working on the asymmetric synthesis of oxygen heterocycles by sigmatropic rearrangement of ylides generated from rhodium carbenoids. In late 1991 he went to Nottingham Polytechnic (now Nottingham Trent University ) working with Dr. Ian G. C. Coutts on the design and synthesis of thiophene heterocycles as calmodulin antagonists. A year later he moved north to the industrial city of Middlesbrough to work with Gurdial Singh at the University of Teesside (formerly Teesside Polytechnic), which was in collaboration with Dr. Richard Wightman of Heriot-Watt University on the synthesis of shikimic acid and analogues from carbohydrates (funded by HEFCE) for which he was awarded a PhD. In early 1996 he moved with Gurdial Singh to the University of Sunderland (formerly Sunderland Polytechnic) and had remained there for six years as a postdoctoral research fellow. His work at Sunderland was sponsored by Fine and Performance Chemicals Ltd on both academic and industrial synthetic chemistry projects and during that time he worked there as the de facto supervisor of the research group.

In late 2002 he moved north of the border to Heriot-Watt University in Edinburgh as a postdoctoral research associate working with Dr. Dave Adams on the synthesis of protein tyrosine phosphatase 1B inhibitors as potential antidiabetic drugs for Scottish Biomedical and the Japanese pharmaceutical company Kyorin. After having driven on the A1 between Sunderland and Edinburgh for six months, he came back to the northeast in May 2003 to work in the University of Newcastle upon Tyne as a postdoctoral research associate with Dr. Mike Carroll on an Amersham sponsored project on fluorine-18 labelled radiopharmaceuticals used in Positron Emission Tomography. He returned back to China in June 2004 and is currently professor of medicinal chemistry at Tianjin University.